Lessons from Theranos - Restructuring Biomedical Innovation.

After raising more than $700 million, Elizabeth Holmes, the founder and chief executive officer of a healthcare startup once valued at $10 billion, was found guilty on four charges of defrauding investors. Founded in 2003, Theranos Inc. was a privately held corporation that aimed to disrupt the diagnostics industry with rapid, direct-to-consumer laboratory testing using only "a drop of blood" and the company's patented Nanotainer technology. By exploiting gaps in regulatory policy, Theranos brought its panel of laboratory tests to patients without pre-market review or validation from peer-reviewed scientific research. Investigations into Theranos' dubious operations and inaccurate test results exposed the failed venture which had squandered millions of dollars. Theranos affected the lives and health of patients further disrupting an already tenuous relationship between healthcare and the public - the importance of which cannot be understated in the setting of the COVID-19 pandemic. As medical systems address a national public health crisis and pervasive structural inequities, we must align stakeholder incentives between industry and academic biomedical innovation to rebuild trust with our patients.

Triboelectric Nanogenerator from Used Surgical Face Mask and Waste Mylar Materials Aiding the Circular Economy.

Apart from claiming the lives of more than 3.2 million people, the COVID-19 pandemic is worsening the global plastic pollution every day, mainly with the overflux of single-use polypropylene (PP) face masks. In this scenario, as an innovative solution to mitigate plastic pollution as well as to meet the rising electrical energy demand, we are introducing an all-flexible and facile waste material-based triboelectric nanogenerator (WM-TENG), aiding toward the circular economy. The WM-TENG operating in contact separation mode is fabricated using the PP from a used face mask in combination with recovered Mylar sheets from solid wastes as triboelectric contact layers and a flexible supporting structure. After detailed investigation and trials to study the effect of various disinfection mechanisms of PP materials on the energy output of WM-TENG, UV-C radiation is selected for disinfecting the used masks owing to the retention of electrical energy output. Under a tapping force of 3 N, the WM-TENG having an active area of 6 cm2 delivers an open-circuit voltage of 200 V and a short-circuit current density of 0.29 mA/m2, respectively. The WM-TENG also delivered a maximum power density of 71.16 mW/m2 under 108 Ω load. Additionally, the WM-TENG is demonstrated for powering electronic gadgets such as a calculator, digital thermometer, and LCD clock. This flexible and low-cost nanogenerator without any complex fabrication steps is a sustainable solution for the alarming plastic pollution as well as the rising energy demands.